Senior Scientist, CAR-T Molecular Profiling & Bioinformatics

Recruiter
Celgene
Location
New Jersey (US)
Salary
Competitive
Posted
29 Jun 2018
Closes
26 Jul 2018
Job Function
Clinical Scientist
Contract Type
Permanent
Hours
Full Time

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Senior Scientist, CAR-T Molecular Profiling and BioinformaticsWarren, NJ

SUPERVISOR

Director, Molecular Profiling and Bioinformatics

DEPARTMENT

Product Science, Cell Therapy Development 

PREREQUISITES

PhD in Bioinformatics, Computational Biology or Biological Sciences with strong quantitative background with at least 6 years of experience, or Master's degree with at least 12 years of experience

Molecular Profiling and Bioinformatics (MPB) team within Product Science group of Cell Therapy Development Department has an exciting opportunity for a highly motivated experienced bioinformatics scientist to join our team. MPB group carries responsibility to identify, develop and implement molecular profiling methods, bioinformatics approaches and data management to enable CQA definition and product characterization. The candidate will be responsible for performing analysis for large scale data sets from different platforms and applications and will develop analysis pipeline for performing such analyses.

Key Responsibilities:

+ Independently conceive, execute, and communicate bioinformatics analysis that support characterizing properties of cell therapy product from candidate nomination through commercial registration - both from the internal Celgene pipeline and from third party collaborations.

+ Develop analysis pipelines for various data sets generated from different platforms and applications from in-house or internal/external collaborators

+ Collaborate with I/O TCoE, RIKU and Translational Development group to advance Celgene cellular immunotherapy and CTD

Qualification and experience:

+ PhD in Bioinformatics, Computational Biology or Biological Sciences with strong quantitative background with at least 6 years of experience, or Master's degree with at least 12 years of experience preferred.

+ The ideal candidates will have solid background in bioinformatics and statistics with strong coding skills in R and an additional programming language such as Perl or Python

+ Proficient with full stack bioinformatics knowledge, tools, and online databases (open source software and R packages) related to data analysis such as gene expression, methylation profiling, network/module analysis, pathway identification, variants calling, copy number variation identification, structural variants identification, single cell analysis and etc

+ Hands on experience with using bioinformatics and statistics tools to perform analysis for large scale, multi-dimensional data from different platforms and applications such as genomics, genetics and epigentics analyses using Next-Gen sequencing or array type platforms (RNA-Seq, Exome-Seq, ChIP-Seq, ATAC-Seq and etc), proteomics data (Mass-Spec or protein arrays), single cell data (single cell RNA-Seq or CyTOF)

+ Candidates must be able to effectively interpret the analysis results within biological context to your peers with different backgrounds

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Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE

At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.

"At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients."

There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.